Our Technology

PolarisImmune Nutrition™

Immune regulation, through the feed.

Polaris Immune Nutrition™ is a patented, fermentation derived paraprobiotic technology that modulates the immune response to preserve wellbeing and productive performance under the full range of immune challenges.

Patented Technology Fermentation Derived GMP+ Certified
What is Polaris Immune Nutrition™

Not a probiotic. Not a vaccine. Something different.

Polaris Immune Nutrition™ is a paraprobiotic technology platform, a defined, fermentation-derived bioactive matrix that interacts with the immune system through the gut, without relying on live microorganisms or disease-specific mechanisms.

Fermentation-Derived Paraprobiotic
Produced through controlled fermentation, Polaris Immune Nutrition™ is a defined composition of bioactive metabolites. No live microorganisms, consistent, scalable, and stable across production batches.
Defined Composition
Feed Additive Format
Delivered via feed inclusion, Polaris Immune Nutrition™ acts through the gut-associated lymphoid tissue, GALT, the largest immune organ in the body. Simple to integrate, no separate administration required.
In-Feed Delivery
Foundational Technology
Polaris Immune Nutrition™ is the scientific core inside DRIPEM products. Its biological activity underpins every immune regulation claim. Designed to work across species, production systems and challenge conditions.
Patented Platform
Built on Proven Science

Decades of research.
One focused technology.

Polaris Immune Nutrition™ was not built overnight. It is the product of more than five years of dedicated laboratory research and two decades of commercial development across species and production systems. The result is a technology with deep scientific roots and a track record of practical application, wherever immune dysregulation stands between animals and their productive potential.

0yrs
Commercial Development
Two decades of refinement across real production environments and challenge conditions
0yrs
Dedicated Lab Research
Intensive immunological and nutritional research to validate the mechanism of action
+species
Cross-Species Application
Validated across species wherever immune dysregulation drives performance loss
The Challenge

Every immune challenge comes at a cost

Viral stress, bacterial infection, microbiome imbalance and environmental stress all trigger the same cascade inside the animal. The immune system activates, and the body's resources are redirected toward fighting the challenge instead of staying healthy and well.

Immune Activation Triggers
What happens inside the animal
Viral Stress
Pathogens dysregulate immune response and exploit weaknesses
Bacterial Infection
Pathogens trigger a prolonged inflammatory response
Microbiome Imbalance
An unbalanced gut flora weakens the first line of defence
Environmental Stress
Heat, density and other external pressures raise the stress load
Immune response dysregulates
The immune system responds too much, too little, or for too long, causing a cascade of negative effects on the wellbeing of the animal
Over-inflammatory reaction
The response overshoots, with inflammation that does more harm than the original challenge itself
Immune defence suppressed
Prolonged dysregulation exhausts the immune system, weakening the animal's ability to respond and leaving it open to further infection
Nutrients diverted from metabolism
Resources that should support normal, healthy metabolic processes are redirected toward fighting the immune challenge instead
The Downstream Problem

The symptoms get treated, not the cause

When immune dysregulation goes unaddressed, the response has historically been antibiotics and repeated vet visits to manage the visible consequences, whether on a farm or at home. Illness, poor recovery and inconsistent health become recurring problems that are treated reactively, cycle after cycle, while the underlying immune imbalance that drives them is rarely targeted directly.

Antibiotic Dependency
Reactive treatment of infections that thrive in immunocompromised animals
Repeated Treatment Cycles and Vet Visits
Each flare up means another course of treatment and another vet visit, and the cycle starts again
Rising Cost of a Healthy Animal
Repeated treatments and vet visits add up, raising the cost of keeping any animal healthy

There is a different approach, one that works at the root of the problem, modulating the immune response itself so that animals stay productive under stress without relying on chemical intervention.

Technology

How Polaris Immune Nutrition™ Works

Watch how Polaris Immune Nutrition™ works, its mode of action, and its application in swine.

Polaris Immune Nutrition™, Mode of Action and Swine Application

Mode of Action

Regulated Immune Response,
even under viral stress.

Polaris Immune Nutrition™ does not boost the immune system indiscriminately, it regulates it. From the first point of contact in the gut, Polaris Immune Nutrition™ guides the immune response through three connected stages, turning a stressed, dysregulated reaction into a controlled and durable one.

01
Dual Receptor Engagement
Delivered through feed, the Polaris Immune Nutrition™ matrix is recognised at the gut-associated lymphoid tissue, GALT, and engages two of the immune system's central innate receptors, TLR2 and TLR4, at the same time. Engaging both together is what produces a controlled response instead of an indiscriminate one.
  • Recognised at the GALT, the body's largest immune interface
  • Engages TLR2 and TLR4 simultaneously
  • A measured trigger, not an indiscriminate stimulant
02
Balanced Th1 Polarisation
Under stress the immune balance tips away from Th1 and toward Th2 and Th17, weakening antiviral defence. Polaris Immune Nutrition™ restores that balance, polarising the response toward Th1 cell-mediated immunity, the pathway built for viral and intracellular pathogens, while keeping Th2 and Th17 in check.
  • Shifts the balance back toward antiviral Th1 immunity
  • Keeps Th2 and Th17 within their healthy range
  • Regulation, not boosting, a measured response
03
Durable Immune Memory
A regulated response is also a lasting one. Polaris Immune Nutrition™ supports the build-up of immunological memory, so animals are primed to respond faster and stronger when challenged again, with protection that holds even after supplementation ends.
  • Builds trained, longer-lasting immune readiness
  • Supports the memory cell populations behind faster recall
  • Protection that persists beyond the feeding window

Polaris Immune Nutrition™ is a nutritional resilience technology. By regulating the immune response from first recognition through to lasting memory, it sustains consistent, efficient productive performance under viral stress.

Scientific Foundation

Grounded in peer-reviewed science

The biological claims supporting Polaris Immune Nutrition™ are underpinned by a body of peer-reviewed literature across immunology, oxidative physiology, protein metabolism and postbiotic science.

TLR2/TLR4 Mode of Action Cross-cutting Oxidative Stress Inflammatory Response Protein Metabolism Immune Memory
1
Zúquete et al. (2024) Combined TLR2/TLR4 activation equips dendritic cells to prime Th1 cells with gut tropism
iScience
2
Mansouri et al. (2025) TLR2 and TLR4 bridge physiological and pathological inflammation
Communications Biology
3
Mukherjee et al. (2016) TLR2 and TLR4-mediated host immune responses in major infectious diseases
Review
4
Beutler et al. (2001) Synergy between TLR2 and TLR4: a safety mechanism
Blood Cells Mol Dis
5
Liu et al. (2007) Signaling via TLR2 and TLR4 down-regulates T-cell effector functions
6
Hirata et al. (2008) Selective synergy in anti-inflammatory cytokine production via TLR4 + TLR2
Mol Immunol
7
Ellen Davis (2022) Immunometabolism and inflammation: a perspective on animal productivity
doi: 10.1093/af/vfac060
8
Hao Y, Xing M, Gu X (2021) Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs
doi: 10.3390/ani11051384
9
Hong, C., Huang, Y., Cao, S. et al. (2024) Accurate models and nutritional strategies for specific oxidative stress factors: Does the dose matter in swine production?
https://doi.org/10.1186/s40104-023-00964-8
10
Sánchez J., et al. (2022) The Connection Between Stress and Immune Status in Pigs: A First Salivary Analytical Panel for Disease Differentiation.
doi: 10.3389/fvets.2022.881435
11
Schroder K, Hertzog PJ, Ravasi T, Hume DA (2004) Interferon-gamma: an overview of signals, mechanisms and functions
doi: 10.1189/jlb.0603252
12
Ayechu-Muruzabal V, Xiao L, et al. (2021) A Fermented Milk Matrix Containing Postbiotics Supports Th1- and Th17-Type Immunity In Vitro and Modulates the Influenza-Specific Vaccination Response In Vivo in Association with Altered Serum Galectin Ratios
doi: 10.3390/vaccines9030254
13
Mafe, A. N., et al. (2025) Postbiotics in Functional Foods: Microbial Derivatives Shaping Health, Immunity and Next-Generation Nutrition
https://doi.org/10.1002/fft2.70205
14
Huster KM., et al. (2004) Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets
doi: 10.1073/pnas.0308054101
15
Xie D, Lu G, Mai G, Guo Q, Xu G. (2020) Tissue-resident memory T cells in diseases and therapeutic strategies
doi: 10.1002/mco2.70053
16
Báez-Magaña M, Alva-Murillo N, et al. (2025) Trained immunity in farm animals
doi: 10.1186/s13567-025-01594-w
17
Williams NH, Stahly TS, Zimmerman DR. (1997) Effect of chronic immune system activation on body nitrogen retention, partial efficiency of lysine utilization, and lysine needs of pigs
doi: 10.2527/1997.7592472x
18
McGilvray WD., et al. (2019) Immune system stimulation induced by porcine reproductive and respiratory syndrome virus alters plasma free amino acid flux and dietary nitrogen utilization in starter pigs
doi: 10.1093/jas/skz120
19
Humphrey B, Zhao J, Faris R. (2019) Review: Link between intestinal immunity and practical approaches to swine nutrition
doi: 10.1017/S1751731119001861

All references relate to peer-reviewed publications supporting the biological mechanisms of Polaris Immune Nutrition™. Internal trial data is documented separately in the DRIPEM Technical Dossier. For professional use only.